
The Skeleton King
Encounter: The Crypt of the Skeleton King
“Defeat the Skeleton King!”
Waypoint The Royal Crypts
Life multiplier 65 · Damage Physical
Game data · Patch 2.8.0

Encounter: The Crypt of the Skeleton King
“Defeat the Skeleton King!”
Waypoint The Royal Crypts
Life multiplier 65 · Damage Physical
Keywarden
Waypoint Fields of Misery
Life multiplier 19 · Damage Physical

Encounter: The Lair of the Spider Queen
“Defeat the Spider Queen!”
Waypoint Caverns of Araneae
Waypoint in Adventure Mode only
Life multiplier 50 · Damage Poison

Encounter: The Butcher's Lair
“Defeat the Butcher!”
Waypoint Halls of Agony Level 3
Life multiplier 70 · Damage Physical

Encounter: The Battle for Caldeum
“Defeat Belial, Lord of Lies!”
Waypoint City of Caldeum
Waypoint in Adventure Mode only
Life multiplier 80

Encounter: Maghda's Den
“Defeat Maghda!”
Waypoint Road to Alcarnus
Life multiplier 35 · Damage Physical, Arcane
Keywarden
Waypoint Dahlgur Oasis
Life multiplier 20 · Damage Physical

Encounter: The Battle for the Black Soulstone
“Retrieve the Black Soulstone at all costs!”
Waypoint Archives of Zoltun Kulle
Life multiplier 32 · Damage Arcane
Encounter: Vidian's Lair
“Defeat the aspect of Envy!”
Waypoint Temple of the Firstborn Level 1
Waypoint in Adventure Mode only
Life multiplier 43 · Damage Physical
Keywarden
Waypoint Stonefort
Life multiplier 21 · Damage Fire, Cold

Encounter: The Larder
“Defeat Ghom, the Lord of Gluttony!”
Waypoint The Keep Depths Level 3
Life multiplier 50 · Damage Physical

Encounter: The Demon Gate
“Defeat the demon Siegebreaker!”
Waypoint Rakkis Crossing
Life multiplier 50 · Damage Physical

Encounter: The Maiden of Lust
“Defeat the Maiden and destroy the final Sin Heart!”
Waypoint Tower of the Cursed Level 1
Life multiplier 30 · Damage Physical

Encounter: Azmodan's Lair
“Defeat the Lord of Sin!”
Waypoint The Core of Arreat
Life multiplier 50 · Damage Physical, Arcane

Encounter: The Library of Fate
“Defeat the demon Despair!”
Waypoint Gardens of Hope 1st Tier
Life multiplier 35 · Damage Physical

Encounter: The Return of Izual
“Defeat Izual!”
Waypoint The Silver Spire Level 1

“Defeat Diablo, Lord of Terror!”
Waypoint The Silver Spire Level 2
Life multiplier 85 · Damage Physical
Keywarden
Waypoint Gardens of Hope 2nd Tier
Life multiplier 20 · Damage Fire

“Defeat Urzael”
Waypoint Westmarch Heights
Life multiplier 100 · Damage Physical


Encounter: Malthael's Lair
“Defeat the aspect of Death!”
Waypoint Pandemonium Fortress Level 2
Life multiplier 135 · Damage Physical
“Defeat the King of the Dead and the Merciless Witch!”
Opened with Infernal Machine of Regret
“Defeat the Foul Desecrator and the Vile Executioner!”
Opened with Infernal Machine of Putridness
“Defeat the Savage Behemoth and the Undying One!”
Opened with Infernal Machine of Terror

“You may already be too late...”

“Free Leah's mother from the minions of Belial!”

“Warn the boy emperor of the machinations of Belial!”

“Azmodan is dead. Celebrate your victory!”

“The battle for heaven is about to begin.”

“Save Deckard Cain!”

“Suffer the horrors that have entrapped generations of Nephalem.”

“Use the Ram to break open the gate to the Pandemonium Fortress.”

“Defeat Greed!”
Life multiplier 75 · Damage Physical

“Help Eirena find her sister, Lysa.”

“Help Shen find the jewel of Dirgest.”

“Search for Lyndon's brother, Edlin, in the Westmarch Dungeons.”

“Help Kormac learn the truth about the corruption of the Templar Order.”
The game files assign every act its waypoints and mark a boss at 21 of them. The list follows that: 17 boss encounters and four Keywardens, act by act in waypoint order. Each card names the boss the way its Adventure Mode bounty does, with the encounter from the boss window below – Rakanoth, for example, waits in "The Library of Fate" and Cydaea in "The Maiden of Lust". Then come the objective from that window, such as "Defeat Ghom, the Lord of Gluttony!", and the waypoint the boss is listed at. All 17 bosses are also available as bounties.
The monster data gives every boss a life multiplier – a multiple of the base life of a monster of the same level; difficulty and rift level come on top. Malthael leads with 135, followed by Adria and Urzael (100 each) and Diablo (85). At the low end of the story bosses are Cydaea (30) and Zoltun Kulle (32); the Keywardens sit at 19 to 21. For comparison: Rift Guardians have 43, most normal monsters 1. The cards also list the damage type – Queen Araneae deals Poison damage, Zoltun Kulle and Adria Arcane damage.
Three of the boss waypoints only exist in Adventure Mode: Caverns of Araneae (Act I), City of Caldeum and Temple of the Firstborn Level 1 (both Act II). All others are available in the campaign and in Adventure Mode; the client lists some of them twice for that, such as The Royal Crypts or Gardens of Hope 2nd Tier. The cards note the three exceptions below the waypoint.
The four Keywardens have fixed waypoints: Odeg the Fields of Misery (Act I), Sokahr Dahlgur Oasis (Act II), Xah'Rith Stonefort (Act III) and Nekarat Gardens of Hope 2nd Tier (Act IV). There are four Uber realms: the Realms of Regret, Putridness and Terror plus the Realm of Fright with Diablo. Their objectives only name the enemies by epithet, such as "the King of the Dead and the Merciless Witch" or "the Soul of Evil".
Story events open a boss window too: saving Deckard Cain, Adria's Prison, the Battle for Heaven or breaching the Pandemonium Fortress. On top come the four events around Eirena, Shen, Lyndon and Kormac, Greed's Lair and the Echoing Nightmare, which the client knows in five versions with their own scenery. One rule applies to every encounter: the party only teleports in once everyone has accepted.
The Butcher belongs to Act I. He is listed at the Halls of Agony Level 3 waypoint, which exists in both the campaign and Adventure Mode.
Odeg at the Fields of Misery waypoint (Act I), Sokahr at Dahlgur Oasis (Act II), Xah'Rith at Stonefort (Act III) and Nekarat at Gardens of Hope 2nd Tier (Act IV).
Four: the Realm of Regret, the Realm of Putridness, the Realm of Terror and the Realm of Fright with Diablo. The Uber bosses guide explains how to open them with Infernal Machines.